Nicknamed the "Whiskey" route because the route is popularized as somewhat difficult and more expensive than Marangu route.

On an overall comparison of the routes to scale Kilimanjaro, this is one of the best routes to take, both in terms of acclimatization and cost.

The Machame route is considered a difficult route, and is better suited for more adventurous trekkers and those with some hiking or backpacking experience.

The Machame route is scenically beautiful and varied. However, due to its popularity there are increased numbers of trekkers, it loses some of its splendour. The Machame route approaches the summit from the southwest and descends using the Mweka route, rewarding climbers with views of the expansive Shira Plateau, an optional scramble up Lava Tower, a climb up the Great Barranco wall, and a traverse underneath Kilimanjaro’s southern ice field.