The Monastery of Saint Anthony is a Coptic Orthodox monastery standing in an oasis in the Eastern Desert of Egypt, in the southern part of the Suez Governorate. Hidden deep in the Red Sea Mountains, it is located 334 km (208 mi) southeast of Cairo. The Monastery of Saint Anthony was established by the followers of Saint Anthony, who is the first Christian monk. The Monastery of St. Anthony is one of the most prominent monasteries in Egypt and has strongly influenced the formation of several Coptic institutions, and has promoted monasticism in general. Several patriarchs have come from the monastery, and several hundred pilgrims visit it each day.

The Monastery of Saint Paul the Anchorite dates to the fourth century AD. It was founded over the cave where Saint Paul the Anchorite lived for more than eighty years. The first travel narrative of the monastery was provided by Antoninus Martyr, a native of Placentia, who visited the tomb of Saint Paul the Anchorite between the years 560 and 570 AD. The first monks to occupy the monastery were some of the disciples of Anthony the Great after they knew the story of Saint Paul the Anchorite it might have been occupied by Melkites for a short period, but they were followed by Egyptian again and Syrian monks. The Syrians may have had a sustained existence at the monastery, for it appears that they also occupied the monastery during the first half of the fifteenth century, after which their presence disappeared. According to an isolated Ethiopian reference, the 70th Coptic Orthodox Pope, Gabriel II (1131–45 AD), was banished to the monastery of Saint Paul the Anchorite for three years.